Architecture has always been a fertile field of experimentation to address and concretely solve the problems of an era, sometimes codifying, starting from contextual needs, conceptual, technical and procedural tools that have radically influenced the course of the history of building. Starting from the genesis of the Modern era up to more recent years, Domus has selected ten “deflagrating” inventions in the ideational approach, processes and products, which greatly anticipate the design themes that are now widely diffused and celebrated by impressive labels (from parametric to bioclimatic architecture, among many others). On the one hand, innovation in compositional principles: from formulations that disrupt the static concept of two-dimensional space (Loos), that reformulate the lexicon of the modern building and recompose it through an updated “anthropocentric” code (Le Corbusier) or through complex mathematical systems (Moretti); to those that unleash the modular construction produced in series (CIAM, Le Corbusier) until transforming it into celebrated authorial expressions on individual dwelling (Case Study Houses programme) and on emergency architecture (Ban). On the other, innovation in operational strategies that, among new techniques (Dieste), efficient building processes (Nervi), employment of unexpected materials (Ban, Blanc), prefigure the genesis of a season of sustainability ante litteram.