Ozempicore: we have entered a new aesthetic of the body?

Born as a diabetes drug, Ozempic has become, in just a few years, a widespread aesthetic: from celebrity faces to social media feeds, producing a new paradigm of the body, fashion, and space.

Ozempicore. The term does not yet exist in any glossary, academic research, or trend report. Yet it describes something that is already everywhere: in our feeds, on the runways, in the hollowed faces of celebrities openly discussed or silently observed, post after post, cover after cover. Ozempicore is a possible name for a cultural condition that has not yet found its word.

Its raw material is pharmacological. Semaglutide, the active ingredient in Ozempic and Wegovy, was developed as a treatment for type 2 diabetes but is also used for weight loss. It slows digestion, suppresses appetite, and produces in a few weeks the kind of weight loss that once required months or years. But the clinical fact is only the trigger. What matters — and what concerns design, space, and material culture — is the speed at which a drug has turned into a diffuse aesthetic, and then into a perceptual paradigm.

There is an implicit architecture within Ozempicore.

“Ozempic face,” a term coined by New York dermatologist Paul Jarrod Frank, describes the hollowing of the face after rapid weight loss: sunken cheeks, protruding cheekbones, sagging skin. The body thins; the face collapses. A paradox that has generated an entire corrective industry of fillers, lifts, biostimulators, and, consequently, a vertically expanding aesthetic market.

On social media, especially Instagram and TikTok, the discourse is already layered. On one side, personal diaries (content shared under #myozempicjourney), whispered “this is just what works for me” confessions in front of mirrors, dietary routines that never name the drug but presuppose it. On the other, forensic videos: slow edits, frame-by-frame montages, timelines of sudden celebrity weight loss, facial proportion analyses with graphic overlays. The algorithm works by accumulation: it repeats, refines, normalizes.

In the 1990s and 2000s, the discourse around body image revolved around traditional media. Now anyone who posts a photo becomes a node in the system. The field extends into fashion with the return of ultra-thin silhouettes on the runway, Y2K nostalgia — low-rise jeans and midriff-baring tops — and a renewed “heroin chic” aesthetic. But Ozempicore exceeds the perimeter of the fashion system. What emerges is a broader reconfiguration of the relationship between bodily discipline and the production of space. There is an implicit architecture within Ozempicore. The idea that the body is a project to be optimized — silently, technologically, without visible effort — produces environments consistent with that premise.

The black market for GLP-1 drugs is thriving. Many off-label injectables are purchased in China, where pens cost fifteen times less than in the United States. Those without access to GLP-1s are turning to “budget Ozempic,” a trendy term for the use of laxatives, which has contributed to shortages of Miralax in the U.S.

The Ozempicore, like all deep conditions, is about how a society negotiates the relationship between visibility and value, showing how what appears desirable is what is recognized as legitimate.